Patent Number: 6,251,620

Title: Three dimensional structure of a ZAP tyrosine protein kinase fragment and modeling methods

Abstract: The invention relates to human ZAP-70, and in particular, to the region of ZAP-70 containing the tandem Src homology-2 ("SH2") domains, to crystalline forms thereof, liganded or unliganded, which are particularly useful for the determination of the three-dimensional structure of the protein. The three dimensional structure of the tandem SH2 region of ZAP provides information useful for the design of pharmaceutical compositions which inhibit the biological function of ZAP and other members of the ZAP family of SH2 domain-containing proteins, particularly those biological functions mediated by molecular interactions involving one or both SH2 domains.

Inventors: Hatada; Marcos H. (Charlestown, MA), Lu; Xiaode (Revere, MA), Laird; Ellen R. (Newton, MA), Karas; Jennifer L. (Lexington, MA), Zoller; Mark J. (Weston, MA), Holt; Dennis A. (Stow, MA)

Assignee: Ariad Pharmaceuticals, Inc.

International Classification: C12N 9/12 (20060101); C12Q 001/48 (); G06F 019/00 ()

Expiration Date: 06/26/2018