Patent Number: 6,251,625

Title: Process for preparing peptides and N-carbamoyl-protected peptides

Abstract: The invention concerns a process for the enzymatic preparation of protected di- and oligopeptides and the separation of the protective groups used. The process according to the invention enables peptides to be synthesized simply and economically and the protective group to be separated carefully. The process comprises three reaction steps: 1. Preparation of N-carbamoyl amino acid or N-carbamoyl amino acid derivatives; 2. Formation of the peptide bond between the carbamoyl-protected electrophile and nucelophile; and 3. Separation of the carbamoyl-protective group.

Inventors: Bommarius; Andreas (Frankfurt, DE), Drauz; Karlheinz (Freigericht, DE), Eichhorn; Uwe (Grosserkammsdorf, DE), Jakubke; Hans-Dieter (Leipzig, DE), Kottenhahn; Matthias (Freigericht, DE)

Assignee: Degussa Aktiengesellschaft

International Classification: C07K 1/06 (20060101); C07K 1/00 (20060101); C12P 21/02 (20060101); C12P 021/06 (); C07K 016/00 ()

Expiration Date: 06/26/2018