Patent Number: 6,251,638

Title: Methods for detection of nucleic acid sequences in urine

Abstract: Described are non-invasive methods of detecting the presence of specific nucleic acid sequences by analyzing urine samples for the presence of nucleic acids that have crossed the kidney barrier. More specifically, the present invention encompasses methods of detecting specific fetal nucleic acid sequences by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of detecting specific nucleic acid alterations for the diagnosis of disease.

Inventors: Umansky; Samuil R. (Richmond, CA), Lichtenstein; Anatoly V. (Moscow, RU), Melkonyan; Hovsep S. (Albany, CA)

Assignee: Diagen Corporation

International Classification: C12Q 1/68 (20060101); C12P 019/34 (); C12Q 001/68 (); G01N 033/00 (); C07H 021/02 (); C07H 021/04 ()

Expiration Date: 06/26/2018