Patent Number: 6,251,645

Title: DEAH-box proteins

Abstract: The present invention relates to the identification and molecular-biological and biochemical characterization of novel DEAH-box proteins which show structural similarity with other known helicases. The invention also relates to DNA sequences encoding such proteins. It is demonstrated that such proteins bind ATP and nucleic acid and possess helicase and ATPase activities. This invention further relates to processes for preparation of such proteins and their use in pharmacologically relevant test systems and therapeutic applications.

Inventors: Kirschbaum; Bernd (Mainz, DE), Muellner; Stefan (Hochheim, DE), Bartlett; Robert (Darmstadt, DE)

Assignee: Aventis Research & Technologies GmbH & Co. KG

International Classification: C07K 14/435 (20060101); C07K 14/47 (20060101); C12N 9/90 (20060101); C12Q 1/68 (20060101); A61K 38/00 (20060101); C12N 009/00 (); C12N 009/12 (); C12N 009/14 (); C12N 009/16 (); C07K 017/00 ()

Expiration Date: 06/26/2018