Patent Number: 6,251,647

Title: Auxiliary genes and proteins of methicillin resistant bacteria and antagonists thereof

Abstract: The present invention is directed to the identification of mutant strains of methicillin resistant bacteria, in particular methicillin resistant Staphylococcus aureus, to identify the characteristics of such bacteria and develop drugs that can reverse, inhibit, or reduce bacterial resistance to beta lactam antibiotics, e.g., methicillin. The invention particularly relates to identification of a novel mutant strain of methicillin resistant S. aureus that manifests a unique phenotype. Accordingly, the invention provides for methods of treatment and corresponding pharmaceutical compositions for treating bacterial, particularly staphylococcal, infections.

Inventors: de Lencastre; Herminia (New York, NY), Tomasz; Alexander (New York, NY)

Assignee: The Rockefeller University

International Classification: A61K 31/429 (20060101); A61K 31/43 (20060101); C07K 14/195 (20060101); C07K 14/31 (20060101); C12N 15/10 (20060101); C12N 15/74 (20060101); C12N 009/10 (); C12N 015/00 ()

Expiration Date: 06/26/2018