Patent Number: 6,251,648

Title: Gene encoding human Dnase

Abstract: A human DNase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating bronchopulmonary conditions. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

Inventors: Rosen; Craig (Laytonsville, MD), Ruben; Steven M. (Olney, MD), Adams; Mark D. (North Potomac, MD)

Assignee: Human Genome Sciences, Inc.

International Classification: C12N 9/22 (20060101); A61K 38/00 (20060101); C12N 009/22 (); A61K 038/00 ()

Expiration Date: 06/26/2018