Patent Number: 6,251,655

Title: Process for increasing the production of penicillin G (benzylpenicillin) in Penicillium chrysogenum by expression of the PCL gene

Abstract: An isolated DNA encoding phenyl acetyl-CoA-ligase and a process of increasing the production of penicillin G in a strain of Penicillium chrysogenum by transforming the strain with the isolated DNA. Also vectors and host organisms having the isolated DNA.

Inventors: Minambres Rodriguez; Baltasar (Leon, ES), Martinez Blanco; Honorina (Leon, ES), Rodriguez Olivera; Elias (Leon, ES), Garcia Alonso; Belen (Leon, ES), Fernandez Canon; Jose Manuel (Madrid, ES), Barredo Fuente; Jose Luis (Leon, ES), Diez Garcia; Bruno (Leon, ES), Schleissner Sanchez; Carmen (Leon, ES), Moreno Valle; Miguel Angel (Leon, ES), Salto Maldonado; Francisco (Madrid, ES), Luengo Rodriguez; Jose Maria (Leon, ES)

Assignee: Antibioticos S.A.

International Classification: C12P 37/00 (20060101); C12P 37/02 (20060101); C12N 9/00 (20060101); C12N 001/20 (); C12N 009/00 (); C12P 037/00 (); C07H 021/04 ()

Expiration Date: 06/26/2018