Patent Number: 6,251,664

Title: Human gene sequence of the down syndrome critical region of human chromosome 21, coding for a serine-threonine protein kinase (MNB), expressed in the neuronal regions affected in down syndrome

Abstract: An isolated human Down Syndrome critical region (MNB) DNA sequence having the nucleotide sequence depicted in SEQ ID NO:1; vector including the human Down Syndrome critical region (MNB) sequence; and isolated host cells containing the vector are provided.

Inventors: Estivill Palleja; Xavier (N/A), N/A (Barcelona, ES), Pritchard; Melanie (Barcelona, ES), Guimera Vilaro; Jordi (Barcelona, ES)

Assignee: Estivill Palleja; Xavier

International Classification: C12Q 1/68 (20060101); C12N 9/12 (20060101); C12N 015/52 (); C12N 015/63 (); C12N 015/85 ()

Expiration Date: 06/26/2018