Patent Number: 6,251,667

Title: Camp-responsive transcriptional enhancer binding protein

Abstract: This invention is directed toward the characterization and cloning of a cAMP-responsive transcription enhancer binding protein (CREB). This protein, CREB, is a transcriptional activator which activates transcription in eukaryotic cells. This CREB protein can be used to increase or decrease production of proteins by stimulating expression of a recombinant gene that is operably-linked to the CRE enhancer element and responsive to cAMP.

Inventors: Habener; Joel F. (Newton Highlands, MA), Hoeffler; James P. (Evergreen, CO)

Assignee: The General Hospital Corporation

International Classification: C07K 14/435 (20060101); C07K 14/47 (20060101); C12N 15/67 (20060101); C12N 15/85 (20060101); C12N 005/10 (); C07K 014/435 ()

Expiration Date: 06/26/2018