Patent Number: 6,251,678

Title: Human papillomavirus vaccine formulations

Abstract: New human papilloma virus (HPV) vaccine formulations exhibit enhanced long-term stability. Formulation components can include: virus-like particles (VLPs) absorbed onto aluminum, a salt, non-ionic surfactant, and a buffer. Additional formulations also contain a polymeric polyanionic stabilizer and a salt either in the presence or absence buffering agents and nonionic detergent.

Inventors: Volkin; David B. (Doylestown, PA), Shi; Li (Eagleville, PA), Mach; Henryk (Ambler, PA)

Assignee: Merck & Co., Inc.

International Classification: A61K 39/12 (20060101); G01N 031/00 (); A61K 039/12 ()

Expiration Date: 06/26/2018