Patent Number: 6,251,687

Title: Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds

Abstract: The invention describes the particles comprising an energy donor as a first component and a fluorescent dye as a second component positioned in said particles at an energy exchanging distance from one another, wherein the two components have a Stokes shift of greater than or equal to 50 nm, said particle having bound on its surface, a protein, polypeptide, nucleic acid, nucleotide or protein containing ligand analogue are disclosed and claimed. In addition, novel fluorescent dyes are described which exhibit intramolecular energy transfer for use to label various molecules, proteins, polypeptides, nucleotides and nucleic acids or to incorporate into particles.

Inventors: Buechler; Kenneth F. (San Diego, CA), Noar; Joseph Barry (Solana Beach, CA), Tadesse; Lema (San Diego, CA)

Assignee: Biosite Diagnostics, Inc.

International Classification: C09B 67/00 (20060101); C09B 47/04 (20060101); C09B 67/02 (20060101); C09B 47/08 (20060101); G01N 33/58 (20060101); G01N 033/543 (); G01N 033/53 (); B05B 005/00 ()

Expiration Date: 06/26/2018