Patent Number: 6,251,689

Title: Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof

Abstract: The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.

Inventors: Laborde; Edgardo (Foster City, CA), Matsumoto; Yukiharu (Foster City, CA)

Assignee: TELIK, Inc.

International Classification: C07D 235/30 (20060101); C07D 263/57 (20060101); C07D 235/18 (20060101); C07D 235/00 (20060101); C07D 277/00 (20060101); C07D 263/58 (20060101); C07D 263/00 (20060101); C07D 277/66 (20060101); C07B 61/00 (20060101); G01N 033/543 ()

Expiration Date: 06/26/2018