Patent Number: 6,251,854

Title: N-methyl-d-aspartate receptor channel blockers and method for identifying such

Abstract: Compounds that provide protection against excitotoxic neuronal damage are selected from the group consisting of Arg-rich oligopeptides and compounds of formula 1: ##STR1## where R.sub.1 is alkyl, alkenyl, or hydroxyalkyl, aminoalkyl, or alkoxy-alkyl; and R.sub.2 and R.sub.3 are each natural or artificial amino acid side chains.

Inventors: Montal; Mauricio (La Jolla, CA), Ferrer-Montiel; Antonio (N/A), N/A (E-03206 Elche, Alicante, ES), Merino; Jaime (N/A), N/A (06080 Badajoz, ES), Blondelle; Sylvie, Houghten; Richard

Assignee:

International Classification: A61K 38/08 (20060101); A61K 31/4188 (20060101); A61K 31/4164 (20060101); C07K 5/072 (20060101); C07K 5/09 (20060101); C07K 7/06 (20060101); C07K 7/00 (20060101); C07D 487/04 (20060101); C07D 487/00 (20060101); C07K 5/00 (20060101); A61K 38/00 (20060101); A61K 038/00 (); A61K 038/02 (); A61K 031/535 (); A01N 037/52 ()

Expiration Date: 06/26/2018