Patent Number: 6,251,856

Title: Insulin derivatives

Abstract: The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the .alpha.-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have a protracted profile of action.

Inventors: Markussen; Jan (Herlev, DK), Jonassen; Ib (Valby, DK), Havelund; Svend (Bagsvaerd, DK), Brandt; Jakob (Bronshoj, DK), Kurtzhals; Peter (Brookline, MA), Hansen; Per Hertz (Lyngby, DK), Kaarsholm; Niels Christian (Vanlose, DK)

Assignee: Novo Nordisk A/S

International Classification: C07K 14/435 (20060101); C07K 14/62 (20060101); C07K 014/62 (); A61K 038/28 ()

Expiration Date: 06/26/2018