Patent Number: 6,251,860

Title: Pharmaceutical preparations

Abstract: The present invention relates to pharmaceutical compositions of transferrin and to the manufacture of such preparations. The present invention concerns specifically a pharmaceutical composition of apotransferrin, the iron-free form of transferrin, wherein the composition has at least 90% of the theoretical iron binding capacity of iron-free transferrin, contains less than 3% transferrin dimers and no detectable transferrin polymers or aggregates, and has an iron-saturation of less than 5%. The pharmaceutical apotransferrin composition of this invention effectively binds non-transferrin-bound-iron to a harmless form when administered as an intravenous injection or infusion to patients. The pharmaceutical composition of this invention does not contain viruses, denatured forms of transferrin or other harmful components.

Inventors: Parkkinen; Jaakko (Espoo, FI), von Bonsdorff-Lindeberg; Leni (Kauniainen, FI)

Assignee: Suomen Punainen Risti Veripalvelu

International Classification: A61K 38/40 (20060101); C07K 14/435 (20060101); C07K 14/79 (20060101); A61K 38/00 (20060101); A61K 038/40 (); C07K 001/18 (); C07K 014/79 ()

Expiration Date: 06/26/2018