Patent Number: 6,251,878

Title: Inhibition of UV-induced immune suppression and interleukin-10 production by cytoprotective tamarind oligosaccharides

Abstract: Methods and compositions are disclosed for the prevention and/or treatment of immunological damage to skin exposed to ultraviolet irradiation. The compositions described herein include biologically active tamarind seed xyloglucan oligosaccharides obtained via treatment of tamarind xyloglucan with a fungal .beta.-glucanase. Advantageously, the cytoprotective tamarind seed xyloglucan oligosaccharides are stable at ambient conditions. In one aspect, the composition includes an aqueous solution of tamarind seed xyloglucan oligosaccharides having a concentration of at least 10.sup.-6 .mu.g per mL of the solution. In another aspect, the method includes preventing the suppression of delayed type hypersensitivity. In yet another aspect, the invention includes reducing the amount of interleukin-10 produced by keratinocytes in the skin.

Inventors: Strickland; Faith (Galveston, TX), Pelley; Ronald (Galveston, TX), Albersheim; Peter (Athens, GA), Darvill; Alan (Athens, GA), Pauly; Markus (Frederiksberg, DK), Eberhard; Stefan (Athens, GA)

Assignee: Board of Regents, The University of Texas System

International Classification: A61K 31/716 (20060101); A61K 031/715 ()

Expiration Date: 06/26/2018