Patent Number: 6,251,887

Title: 17.beta.-aryl(arylmethyl)oxy(thio)alkyl-androstane derivatives

Abstract: The invention relates to 17.beta.-aryl(arylmethyl)oxy(thio)alkyl-androstane derivatives having general formula (I), wherein R.sub.1 is (H,OR), (H,OSO.sub.3 H) or NOR; with R being H, (C.sub.1-6)alkyl or (C.sub.1-6)acyl; each of R.sub.2 and R.sub.3 is independently hydrogen or (C.sub.1-6)alyl; n is 0, 1, or 2; X is O, S, S(O) or S(O).sub.2 ; m is 0 or 1; each of R.sub.4, R.sub.5 and R.sub.6 is independently hydrogen, hydroxy, (C.sub.1-4)alkoxy, halogen, NR.sub.7 R.sub.8 or (C.sub.1-4)alkyl, optionally substituted by hydroxy, alkoxy, halogen or oxo; each of R.sub.7 and R.sub.8 is independently hydrogen or (C.sub.1-4)alkyl, and wherein the dotted lines indicate a .DELTA..sup.7 or a .DELTA..sup.8 double bond, or a pair of conjugated double bonds selected from .DELTA..sup.7,14, .DELTA..sup.8,14 and .DELTA..sup.6,8(14) ; or a pharmaceutically acceptable salt thereof. The compounds of the invention have meiosis regulating activity and can be used for the control of fertility. ##STR1##

Inventors: Heijmans; Christian (Breda, NL), van der Louw; Jaap (Oss, NL)

Assignee: Akzo Nobel N.V.

International Classification: C07J 9/00 (20060101); C07J 51/00 (20060101); C07J 7/00 (20060101); C07J 007/00 (); C07J 009/00 (); C07J 051/00 (); C07J 031/575 (); C07J 003/00 (); A61K 031/33 (); A61K 031/00 ()

Expiration Date: 06/26/2018