Patent Number: 6,251,890

Title: Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Abstract: The present invention relates to carbapenem antibacterial agents of formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R.sup.2 represents: ##STR2## in formula I, in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a CH.sub.2 group. The naphthosultam is further substituted with various substituent groups including at least one cationic group.

Inventors: Blizzard; Timothy A. (Rahway, NJ), Ratcliffe; Ronald W. (Matawan, NJ), Morgan, II; Jerry D. (Piscataway, NJ), Wilkening; Robert R. (Maplewood, NJ)

Assignee: Merck & Co., Inc.

International Classification: C07D 477/14 (20060101); C07D 477/00 (20060101); C07D 477/14 (); C07D 516/06 (); A61P 031/04 (); A61K 031/474 (); A61K 031/474 ()

Expiration Date: 06/26/2018