Patent Number: 6,251,892

Title: N-oxides of heterocyclic esters, amides, thioesters, and ketones

Abstract: This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters, amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.

Inventors: Hamilton; Gregory S. (Catonsville, MD), Steiner; Joseph P. (Hampstead, MD), Burak; Eric S. (Forest Hill, MD)

Assignee: GPI NIL Holdings, Inc.

International Classification: C07D 401/00 (20060101); C07D 401/12 (20060101); A61K 031/55 (); A61K 031/47 (); C07D 223/10 (); C07D 211/60 (); C07D 207/00 ()

Expiration Date: 06/26/2018