Patent Number: 6,251,894

Title: 1-(1,2-disubstituted piperidinyl)-4 (fused imidazole)-piperidine derivatives

Abstract: This invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 0, 1 or 2; m is 1 or 2, provided that if m is 2, then n is 1; .dbd.Q is .dbd.O or .dbd.NR.sup.3 ; X is a covalent bond or --O--, --S--, --NR.sup.3 --; R.sup.1 is Ar.sup.1, Ar.sup.1 C.sub.1-6 alkyl or di(Ar.sup.1)C.sub.1-6 alkyl, wherein each C.sub.1-6 alkyl group is optionally substituted; R.sup.2 is Ar.sup.2, Ar.sup.2 C.sub.1-6 alkyl, Het or HetC.sub.1-6 alkyl; R.sup.3 is hydrogen or C.sub.1-6 alkyl; L is a piperidine derivative of formula (a-1) or a spiro piperidine derivative of formula (a-2); Ar.sup.1 is phenyl or substituted phenyl; Ar.sup.2 is naphtalenyl; phenyl or substituted phenyl; and Het is a monocyclic or bicyclic heterocycle; each monocyclic and bicyclic heterocycle may optionally be substituted on a carbon atom; as substance P antagonists; their preparation, compositions containing them and their use as a medicine.

Inventors: Janssens; Frans Eduard (Bonheiden, BE), Leenaerts; Joseph Elisabeth (Rijkevorsel, BE), Van Roosbroeck; Yves Emiel Maria (Hallaar, BE)

Assignee: Janssen Pharmaceuticals N.V.

International Classification: C07D 471/00 (20060101); C07D 471/04 (20060101); C07D 487/00 (20060101); C07D 495/00 (20060101); C07D 487/04 (20060101); C07D 471/20 (20060101); C07D 487/14 (20060101); C07D 495/14 (20060101); A01N 043/46 (); A61K 031/55 (); C07D 515/00 (); C07D 487/00 ()

Expiration Date: 06/26/2018