Patent Number: 6,251,897

Title: 6-phenyltetrahydro-1,3-oxazin-2-one derivative and pharmaceutical composition containing the same

Abstract: A 6-phenyltetrahydro-1,3-oxazin-2-one derivative having the formula (I): ##STR1## wherein, R.sub.1 is an unsubstituted or substituted C.sub.1 to C.sub.8 alkyl group; an unsubstituted or substituted C.sub.3 to C.sub.7 cycloalkyl group;, etc., R.sub.2 is a C.sub.1 to C.sub.4 alkyl group, R.sub.3 is H; an unsubstituted or substituted C.sub.1 to C.sub.5 alkyl group; etc., R.sub.4 is H; an unsubstituted or substituted C.sub.1 to C.sub.6 alkyl group, and R.sub.5 and R.sub.6 are independently a hydrogen atom; an unsubstituted or substituted C.sub.1 to C.sub.5 alkyl group; etc. an optical isomer thereof, or a pharmacologically acceptable salt thereof, or a hydrate or a solvate thereof and pharmaceutical compositions containing the same, in particular a drug for the prevention or treatment of inflammatory diseases and a drug for asthma. The above 6-phenyltetrahydro-1,3-oxazin-2-one derivative has a strong type IV PDE inhibitory activity and has a bronchiodilator and antiinflammatory effects.

Inventors: Ina; Shinji (Omiya, JP), Yamana; Kenjirou (Omiya, JP), Noda; Kyoji (Omiya, JP)

Assignee: Nikken Chemicals Co., LTD

International Classification: C07D 265/00 (20060101); C07D 265/10 (20060101); C07D 413/00 (20060101); C07D 413/06 (20060101); C07D 413/04 (20060101); C07D 413/12 (20060101); C07D 417/04 (20060101); C07D 417/12 (20060101); C07D 417/00 (20060101); A61K 031/535 (); A61P 011/06 (); A61P 017/04 (); C07D 265/10 ()

Expiration Date: 06/26/2018