Patent Number: 6,251,903

Title: Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones and the use thereof as glycine receptor antagonist

Abstract: Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia, and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, and inducing anesthesia are disclosed by administering to an animal in need of such treatment an alkyl or azido-substituted 1,4-dihydroquinoxaline-2,3-dione or pharmaceutically acceptable salts thereof, which have high binding to the glycine receptor.

Inventors: Cai; Sui Xiong (Irvine, CA), Weber; Eckard (Laguna Beach, CA), Keana; John F. W. (Eugene, OR), Kher; Sunil (Eugene, OR)

Assignee: Cocensys, Inc.

International Classification: A61K 51/04 (20060101); A61K 51/02 (20060101); C07D 241/00 (20060101); C07D 241/44 (20060101); C07D 241/38 (20060101); C07D 487/00 (20060101); C07D 487/04 (20060101); C07D 491/00 (20060101); C07D 491/04 (20060101); A61K 031/495 ()

Expiration Date: 06/26/2018