Patent Number: 6,251,908

Title: Piperazine derivatives

Abstract: Piperazine derivatives of the formula I ##STR1## in which R.sup.1, m, k and R.sup.2 have the meanings indicated in claim 1, are potent 5-HT.sub.1A agonists and exhibit 5-HT-reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depression, schizophrenia, obsessions, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive disorder, and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.

Inventors: Bottcher; Henning (Darmstadt, DE), Bartoszyk; Gerd (Darmstadt, DE), Greiner; Hartmut (Darmstadt, DE), Seyfried; Christoph (Darmstadt, DE)

Assignee: Merck Patent Gesellschaft mit beschraenkter Haftung

International Classification: C07D 405/00 (20060101); C07D 405/12 (20060101); C07D 405/14 (); A61K 031/496 ()

Expiration Date: 06/26/2018