Patent Number: 6,251,909

Title: Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds

Abstract: The invention relates to new arylglycinamide derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1 and R.sup.2 together with the N to which they are bound form a ring of the formula ##STR2## wherein p is 2 or 3 and X denotes oxygen, N(CH.sub.2).sub.n R.sup.6 or CR.sup.7 R.sup.8, and R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, Ar and n have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.

Inventors: Schnorrenberg; Gerd (Gau-Algesheim, DE), Dollinger; Horst (Ingelheim am Rhein, DE), Esser; Franz (Ingelheim am Rhein, DE), Briem; Hans (Budenheim, DE), Jung; Birgit (Bigen, DE), Speck; Georg (Ingelheim am Rhein, DE)

Assignee: Boehringer Ingelheim KG

International Classification: C07D 211/66 (20060101); C07D 211/58 (20060101); C07D 295/145 (20060101); C07D 295/00 (20060101); C07D 471/00 (20060101); C07D 401/00 (20060101); C07D 401/04 (20060101); C07D 401/12 (20060101); C07D 471/10 (20060101); C07D 211/00 (20060101); C07D 211/62 (20060101); C07D 211/64 (20060101); A61K 031/495 (); A61P 019/02 (); C07O 295/15 ()

Expiration Date: 06/26/2018