Patent Number: 6,251,911

Title: Pyrimidine derivatives and processes for the preparation thereof

Abstract: 4-Amino-1H-pyrazolo[3,4-d]pyrimidine derivatives of formula I ##STR1## wherein the substituents are as defined in claim 1, are described. These compounds inhibit the tyrosine kinase activity of the receptor for epidermal growth factor (EGF) and c-erbB2 kinase and can be used as anti-tumor agents.

Inventors: Bold; Guido (Gipf-Oberfrick, CH), Frei; Jorg (Holstein, CH), Lang; Marc (Mulhouse, FR), Traxler; Peter (Schonenbuch, CH)

Assignee: Novartis AG

International Classification: C07D 487/00 (20060101); C07D 487/04 (20060101); C07D 487/04 (); A61K 031/505 ()

Expiration Date: 06/26/2018