Patent Number: 6,251,912

Title: Substituted quinazoline derivatives

Abstract: This invention provides compounds of formula 1 having the structure ##STR1## wherein: X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, Z, X, and n are as defined hereinbefore in the specification, which are useful as antineoplastic agents and in the treatment of certain kidney diseases, such as polycystic kidney disease.

Inventors: Wissner; Allan (Ardsley, NY), Tsou; Hwei-Ru (New City, NY), Johnson; Bernard D. (Stony Point, NY), Hamann; Philip R. (Garnerville, NY), Zhang; Nan (Suffern, NY)

Assignee: American Cyanamid Company

International Classification: C07D 239/00 (20060101); C07D 239/94 (20060101); A61K 031/517 (); C07D 239/88 (); C07D 239/93 (); C07D 239/94 ()

Expiration Date: 06/26/2018