Patent Number: 6,251,921

Title: Antithrombotic diamines

Abstract: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.

Inventors: Bastian; Jolie Anne (Beech Grove, IN), Chirgadze; Nickolay Yuri (Carmel, IN), Denney; Michael Lyle (Franklin, IN), Fisher; Matthew Joseph (Carmel, IN), Foglesong; Robert James (Durham, NC), Harper; Richard Waltz (Indianapolis, IN), Johnson; Mary George (Durham, NC), Klimkowski; Valentine Joseph (Carmel, IN), Kohn; Todd Jonathan (Fishers, IN), Lin; Ho-Shen (Indianapolis, IN), Lynch; Michael Patrick (Raleigh, NC), McCowan; Jefferson Ray (Indianapolis, IN), Palkowitz; Alan David (Carmel, IN), Richett; Michael Enrico (Indianapolis, IN), Sall; Daniel Jon (Greenwood, IN), Smith; Gerald Floyd (Indianapolis, IN), Takeuchi; Kumiko (Indianapolis, IN), Tinsley; Jennifer Marie (Martinsville, IN), Zhang; Minsheng (Nutley, NJ)

Assignee: Eli Lilly and Company

International Classification: A61K 31/422 (20060101); A61K 31/4427 (20060101); A61K 31/4178 (20060101); A61K 31/381 (20060101); A61K 31/4025 (20060101); A61K 31/4439 (20060101); A61K 31/4164 (20060101); A61K 31/5377 (20060101); A61K 31/55 (20060101); A61K 31/454 (20060101); A61K 31/4545 (20060101); A61K 31/497 (20060101); A61K 31/4965 (20060101); A61K 31/5375 (20060101); A61K 31/4523 (20060101); C07D 409/00 (20060101); C07D 333/00 (20060101); C07D 333/64 (20060101); C07D 409/06 (20060101); C07D 413/00 (20060101); C07D 409/12 (20060101); C07D 521/00 (20060101); C07D 409/04 (20060101); C07D 413/06 (20060101); C07D 333/56 (20060101); C07D 333/66 (20060101); C07D 333/58 (20060101); C07D 333/62 (20060101); A61K 031/443 (); C07D 405/14 (); C07D 409/12 (); C07D 409/14 (); A61P 007/02 ()

Expiration Date: 06/26/2018