Patent Number: 6,251,928

Title: Treatment of alzheimer's disease employing inhibitors of cathepsin D

Abstract: This invention provides novel benzylidene rhodanines which are useful as agents in treating or preventing conditions associated with .beta.-amyloid peptide. This invention further provides methods of treating or preventing Alzheimer's Disease which comprises administering to a mammal in need thereof an effective amount of one or more of the benzylidene rhodanines of the present invention.

Inventors: Panetta; Jill A. (Zionsville, IN), Phillips; Michael L. (Indianapolis, IN), Reel; Jon K. (Carmel, IN), Shadle; John K. (Fishers, IN), Sigmund; Sandra K. (Indianapolis, IN), Simon; Richard L. (Greenwood, IN), Whitesitt; Celia A. (Greenwood, IN)

Assignee: Eli Lilly and Company

International Classification: C07D 277/00 (20060101); C07D 277/20 (20060101); C07D 417/12 (20060101); C07D 417/00 (20060101); A61K 031/427 ()

Expiration Date: 06/26/2018