Patent Number: 6,251,936

Title: Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia

Abstract: This invention provides compounds of Formula I having the structure ##STR1## E is S, SO, SO.sub.2, O, or NR.sup.1c ; X is hydrogen, halogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, CN, aryl, aralkyl of 6-12 carbon atoms, hydroxyalkyl of 1-6 carbon atoms, hydroxyaralkyl of 6-12 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, aryloxy; arylalkoxy, nitro, amino, NR.sup.2 R.sup.2a, NR.sup.2 COR.sup.2a, cycloalkylamino of 3-8 carbon atoms, morpholino, alkylsulfanyl of 1-6 carbon atoms, arylsulfanyl, pyridylsulfanyl, 2-N,N-dimethylaminoethylsulfanyl, --OCH.sub.2 CO.sub.2 R.sup.2b or --COR.sup.2c ; Z.sup.1 and Z.sup.2 are each, independently, hydrogen, halogen, CN, alkyl of 1-6 carbon atoms, aryl, aralkyl of 6-12 carbon atoms, cycloalkyl of 3-8 carbon atoms, nitro, amino, --NR.sup.1 R.sup.1a, --NR.sup.1 COR.sup.1a, cycloalkylamino of 3-8 carbon atoms, morpholino, or OR.sup.8, or Z.sup.1 and Z.sup.2 may be taken together as a diene unit having the formula --CH.dbd.CR.sup.9 --CR.sup.10.dbd.CR.sup.11 --; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

Inventors: Wrobel; Jay E. (Lawrenceville, NJ), Dietrich; Arlene J. (Delran, NJ), Antane; Madelene M. (Lawrenceville, NJ)

Assignee: American Home Products Corporation

International Classification: C07D 307/00 (20060101); C07D 333/00 (20060101); C07D 307/92 (20060101); C07D 333/56 (20060101); C07D 333/74 (20060101); C07D 333/74 (); A61K 031/381 ()

Expiration Date: 06/26/2018