Patent Number: 6,251,939

Title: Carbamate-based cationic lipids

Abstract: The present invention provides novel carbamate-based cationic lipids of the general structure: ##STR1## or a salt, or solvate, or enantiomers thereof, wherein (a) R.sub.1 is a lipophilic moiety; (b) R.sub.2 is a positively charged moiety; (c) n is an integer from 1 to 8; (d) X is an anion or polyanion; and (e) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions, and a kit for preparing the same.

Inventors: Schwartz; David Aaron (Encinitas, CA), Brown; Bob Dale (Encinitas, CA), Dwyer; Brian Patrick (San Diego, CA)

Assignee: Promega Biosciences, Inc.

International Classification: A61K 9/127 (20060101); C07C 271/20 (20060101); C07C 271/00 (20060101); C07J 41/00 (20060101); C07J 43/00 (20060101); C07J 51/00 (20060101); C07K 5/02 (20060101); C07K 5/00 (20060101); A61K 031/215 (); C07C 271/00 ()

Expiration Date: 06/26/2018