Patent Number: 6,251,941

Title: Use of inhaled retinoids in the prevention of cancer

Abstract: Administration of retinoids by inhalation is used to overcome the chronic toxicity problems presented by systemic administration and to make retinoid therapy available as an option for the prevention of epithelial cancers of the respiratory tract, especially those that are associated with tobacco use. Retinoids are administered by inhalation to the respiratory tract of the individual as an air-borne composition with a metered dose aerosol-producing inhaler, in which the retinoid is dissolved in a combination of a pharmaceutically acceptable chlorofluorocarbon propellant and an alkylamine solubilizing agent.

Inventors: Tong; William P. (Flushing, NY), Warrell; Raymond P. (Westfield, NJ)

Assignee: Sloan-Kettering Institute for Cancer Research

International Classification: A61K 31/045 (20060101); A61K 31/07 (20060101); A61K 31/167 (20060101); A61K 47/16 (20060101); A61K 31/192 (20060101); A61K 31/185 (20060101); A61K 47/18 (20060101); A61K 31/203 (20060101); A01N 037/00 (); A61K 031/20 ()

Expiration Date: 06/26/2018