Patent Number: 6,251,942

Title: Compositions and methods for alleviating impaired mental function, memory loss and reducing recovery time in anaesthetized mammals

Abstract: Composition and methods of alleviating impaired mental function and memory loss in mammals and reducing the recovery time from anaesthesia in age mammals, comprising treating the mammal with a non-toxic, enhancing effective amount of a cell membrane permeant calcium buffer. The buffer is preferably a calcium ion chelating agent having a K.sub.D selected from the range 1.times.10.sup.-4 to 1.times.10.sup.-8 Molar and being essentially calcium ion-selective over other metal ions. A most preferred buffer is BAPTA-AM.

Inventors: Carlen; Peter Louis (Toronto, Ontario, CA), Janus; Christopher George (Toronto, CA), El-Beheiry; Hossam (Mississauga, CA)

Assignee: Carlen; Peter Louis

International Classification: A61K 31/00 (20060101); A61K 31/198 (20060101); A61K 31/185 (20060101); A61K 31/225 (20060101); A61K 31/21 (20060101); A61K 31/195 (20060101); A61K 031/195 ()

Expiration Date: 06/26/2018