Patent Number: 6,251,944

Title: Para-substituted phenylene derivatives

Abstract: The present invention relates to a class of compounds represented by Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v.beta..sub.3 integrin.

Inventors: Chen; Barbara B. (Glenview, IL), Chen; Helen Y. (Livingston, NJ), Gesicki; Glen J. (Morton Grove, IL), Haack; Richard A. (Chicago, IL), Malecha; James W. (Libertyville, IL), Penning; Thomas D. (Elmhurst, IL), Rico; Joseph G. (Ballwin, MO), Rogers; Thomas E. (Ballwin, MO), Ruminski; Peter G. (Dardenne Prairie, MO), Russell; Mark A. (Gurnee, IL), Yu; Stella S. (Morton Grove, IL)

Assignee: G. D. Searle & Company

International Classification: A61K 31/155 (20060101); C07C 311/19 (20060101); C07C 311/06 (20060101); C07C 323/00 (20060101); C07C 311/64 (20060101); C07C 317/00 (20060101); C07C 275/42 (20060101); C07C 323/52 (20060101); C07C 311/00 (20060101); C07C 311/13 (20060101); C07C 317/44 (20060101); C07C 279/28 (20060101); C07D 233/88 (20060101); C07C 279/00 (20060101); C07D 233/50 (20060101); C07C 275/00 (20060101); C07D 239/00 (20060101); C07D 295/215 (20060101); C07D 233/00 (20060101); C07C 279/18 (20060101); C07C 279/22 (20060101); C07C 279/24 (20060101); C07D 271/00 (20060101); C07D 249/14 (20060101); C07D 249/00 (20060101); C07D 239/14 (20060101); C07D 521/00 (20060101); C07D 295/00 (20060101); C07D 223/12 (20060101); C07D 271/07 (20060101); C07D 223/00 (20060101); A61K 031/19 (); C07C 229/00 (); C07C 205/00 ()

Expiration Date: 06/26/2018