Patent Number: 6,251,946

Title: Branched chain fatty acids, their derivatives and use in the treatment of central nervous system disorders

Abstract: A compound having formula (I): wherein R.sub.1 is a saturated or unsaturated chain of 1-5 carbons in length; and R.sub.2 is a saturated or unsaturated chain of 3-10 carbons in length; and A is selected from the group consisting of COOL and CONR'--R", wherein L is a lipid moiety selected from the group consisting of glycerol, C.sub.3-20 fatty acid monoglycerides, C.sub.3-20 fatty acid diglycerides, hydroxy-C.sub.2-6 -alkyl esters of C.sub.3-20 fatty acids, hydroxy-C.sub.2-6 -alkyl esters of lysophosphatidic acids, lyso plasmalogens, lysophospholipids, lysophosphatidic acid amides, glycerophosphoric acids, sphingolipids, lysophosphatidylethanolamines, and N-mono and N,N-di-(C.sub.1-4)alkyl derivatives of the amines thereof; and R' and R" are each independently selected from the group consisting of hydrogen and a lower alkyl group comprising 1-5 carbon atoms; and pharmaceutically acceptable salts thereof. In addition, there is provided methods for using these compositions. ##STR1##

Inventors: Vinikova; Marina (Ramla, IL), Kozak; Alexander (Rehovot, IL), Shapiro; Israel (Ramla, IL)

Assignee: D-Pharm Ltd.

International Classification: C07C 69/00 (20060101); C07C 233/05 (20060101); C07C 233/00 (20060101); C07F 9/10 (20060101); C07C 69/30 (20060101); C07F 9/00 (20060101); C07C 53/00 (20060101); C07C 53/128 (20060101); A01N 037/18 ()

Expiration Date: 06/26/2018