Patent Number: 6,251,950

Title: Aliphatic propargylamines as cellular rescue agents

Abstract: The present invention relates to the use of a group of propargylamines of the general formula (I) ##STR1## wherein R.sup.1 is hydrogen or CH.sub.3 and R.sup.2 is (CH.sub.2).sub.n CH.sub.3 and n is an integer from 0 to 16, and salts thereof, as cellular rescue agents in the treatment and prevention of diseases in which cell death occurs by apoptosis. Some of the compounds of formula I are novel. The invention is also directed to the use of these compounds in the treatment of these diseases, as well as to processes for the preparation of the compounds.

Inventors: Durden; David (Saskatchewan, CA), Paterson; Alick (Saskatchewan, CA), Davis; Bruce (Saskatchewan, CA), Dyck; Lillian (Saskatchewan, CA), Yu; Peter (Saskatchewan, CA), Li; Xinmin (Saskatchewan, CA), Boulton; Alan (Saskatchewan, CA)

Assignee: University of Saskatchewan

International Classification: C07C 211/00 (20060101); C07C 211/23 (20060101); A61K 031/13 ()

Expiration Date: 06/26/2018