Patent Number: 6,251,957

Title: Method of reducing an immune response to a recombinant virus

Abstract: A method of reducing immune response to a viral vector containing a selected transgene is provided. The method involves co-administration of the viral vector and a selected immune modulator capable of inhibiting the formation of neutralizing antibodies and/or CTL elimination of the vectors upon repeated administration.

Inventors: Wilson; James M. (Gladwyne, PA), Yang; Yiping (Philadelphia, PA), Trinchieri; Giorgio (Wynnewood, PA)

Assignee: Trustees of the University of Pennsylvania

International Classification: A61K 35/76 (20060101); A61K 35/66 (20060101); A61K 39/395 (20060101); A61K 38/20 (20060101); A61K 38/21 (20060101); A61K 48/00 (20060101); C12N 15/861 (20060101); A01N 043/04 (); A61K 031/70 (); C12N 015/63 (); C12N 015/00 ()

Expiration Date: 06/26/2018