Patent Number: 6,251,964

Title: Biocompatible compositions

Abstract: A polymer is formed from monomers including a zwitterionic monomer, a cationic monomer and a hydrophobic termonomer. The polymer may be cross-linkable. The polymer may be coated onto a surface from a liquid coating composition followed by contacting the coated surface with heparin. The double coated substrates have improved heparin activity over extended periods as compared to heparinised surfaces which are commercially available. Other anionically charged mucopolysaccharides may be used. The polymers may also scavenge heparin from treated blood to avoid use of potentially toxic heparin inhibitors. Preferably the terpolymer is formed from 2-methacryloyloxyethyl-2-(trimethylamonium)phosphate inner salt, choline methacrylate and n-dodecyl methacrylate.

Inventors: Porssa; Manuchehr (Surrey, GB), McNeillis; Paul Matthew (Surrey, GB), Freeman; Richard Neil Templar (Surrey, GB)

Assignee: Biocompatibles Limited

International Classification: A61L 33/00 (20060101); A61K 031/715 (); C08L 101/04 (); C08L 101/06 (); C08L 005/04 (); C08L 005/10 ()

Expiration Date: 06/26/2018