Patent Number: 6,252,041

Title: Depsipeptides containing non-natural amino acids

Abstract: A depsipeptide containing a non-natural amino acid(s) having the formula (1) ##STR1## wherein R.sup.1 represents a C.sub.5 -C.sub.20 alkyl group and others; R.sup.2 represents --O--CO--CH(R.sup.5)--X--CH(R.sup.6)--NH-- (wherein X represents N(R.sup.7)--CO, CH.sub.2 --CO, CH.sub.2 --CH.sub.2 and others, R.sup.5, R.sup.6, and R.sup.7 represent a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group); R.sup.3 represents ##STR2## and wherein the remaining substituent variables are as defined herein. The above depsipeptides have a promoting activity on the production of apolipoprotein E, and are useful as a therapeutic agent for neurologic damages, especially dementia, and hyperlipemia.

Inventors: Yanai; Makoto (Saitama-ken, JP), Suzuki; Masashi (Saitama-ken, JP), Oshida; Norio (Saitama-ken, JP), Kawamura; Koji (Saitama-ken, JP), Hiramoto; Shigeru (Saitama-ken, JP), Yasuda; Orie (Saitama-ken, JP), Kinoshita; Nobuhiro (Saitama-ken, JP), Shingai; Akiko (Saitama-ken, JP), Takasu; Masako (Saitama-ken, JP)

Assignee: Nisshin Flour Milling Co., Ltd.

International Classification: C07C 237/10 (20060101); C07C 237/00 (20060101); C07K 5/103 (20060101); C07K 5/06 (20060101); C07K 5/00 (20060101); A61K 38/00 (20060101); C07K 005/08 ()

Expiration Date: 06/26/2018