Patent Number: 6,252,045

Title: Human occludin, its uses and enhancement of drug absorption using occludin inhibitors

Abstract: The gene for occludin, an integral transmembrane protein specifically associated with tight junctions that functions in forming intercellular seal, is cloned, characterized, and sequenced, and the polypeptide sequence determined. Drug delivery is enhanced by administering an effective amount of occludin inhibitors. These include peptides or antibodies that interact with occludin or occludin receptors. Also included are occludin antagonists, occludin receptor components, and mixtures thereof. In some embodiments, analogues of occludin surface loops that inhibit adhesion and/or barrier properties are employed. Administration can be local or systemic; local administration in a pharmaceutically acceptable carrier is preferred in some embodiments.

Inventors: Anderson; James M. (New Haven, CT), Van Itallie; Christina M. (New Haven, CT)

Assignee: Yale University

International Classification: C07K 14/435 (20060101); C07K 14/705 (20060101); C07K 14/47 (20060101); G01N 33/50 (20060101); C07K 001/00 ()

Expiration Date: 06/26/2018