Patent Number: 6,252,047

Title: Reagents and methods useful for detecting diseases of the prostate

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

Inventors: Billing-Medel; Patricia A. (Gurnee, IL), Cohen; Maurice (Highland Park, IL), Colpitts; Tracey L. (Round Lake, IL), Friedman; Paula N. (Deerfield, IL), Gordon; Julian (Lake Bluff, IL), Granados; Edward N. (Vernon Hills, IL), Hodges; Steven C. (Buffalo Grove, IL), Klass; Michael R. (Libertyville, IL), Kratochvil; Jon D. (Kenosha, WI), Roberts-Rapp; Lisa (Gurnee, IL), Russell; John C. (Pleasant Prairie, WI), Stroupe; Stephen D. (Libertyville, IL), Yu; Hong (Buffalo Grove, IL)

Assignee: Abbott Laboratories

International Classification: C07K 16/18 (20060101); C07K 16/30 (20060101); C12Q 1/68 (20060101); A61K 38/00 (20060101); C07K 013/00 (); C07K 015/28 ()

Expiration Date: 06/26/2018