Patent Number: 6,252,050

Title: Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method

Abstract: A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically cross-react with two or more different receptors to which Apo-2 ligand (Apo-2L) can bind.

Inventors: Ashkenazi; Avi J. (San Mateo, CA), Chuntharapai; Anan (Colma, CA), Kim; K. Jin (Los Altos, CA)

Assignee: Genentech, Inc.

International Classification: C07K 16/18 (20060101); C07K 16/28 (20060101); A61K 039/395 (); C07K 016/28 ()

Expiration Date: 06/26/2018