Patent Number: 6,252,058

Title: Sequences for targeting metastatic cells

Abstract: The present invention relates to methods for the diagnosis, evaluation and treatment of metastatic diseases using metastatic sequences, such as caveolin, to target metastatic cells. According to the methods of the present invention, certain cancers, including metastatic prostate cancer, may be treated by therapies which suppress expression of the caveolin gene. The present invention relates to biological technologies designed to block the activity of caveolin or the function of caveolae, including vector delivery of antisense caveolin sequences, the use of anti-caveolin antibodies, the use of promoters, and other approaches targeting the expression of caveolin.

Inventors: Thompson; Timothy C. (Houston, TX)


International Classification: C07K 14/435 (20060101); C07K 14/705 (20060101); C12N 15/11 (20060101); A61K 38/00 (20060101); A61K 48/00 (20060101); C07H 021/04 (); C12Q 001/68 (); A61K 048/00 (); C12N 015/00 ()

Expiration Date: 06/26/2018