Patent Number: 6,252,070

Title: Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

Abstract: The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 ##STR1## The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.

Inventors: Bunker; Amy Mae (Middletown, CT), Cheng; Xue-Min (Ann Arbor, MI), Doherty; Annette Marian (Paris, FR), Edmunds; Jeremy John (Ypsilanti, MI), Kanter; Gerald David (West Bloomfield, MI), Lee; Chitase (Ann Arbor, MI), Repine; Joseph Thomas (Ann Arbor, MI), Skeean; Richard William (Ann Arbor, MI)

Assignee: Warner-Lambert Company

International Classification: C07D 279/02 (20060101); C07D 417/10 (20060101); C07D 417/04 (20060101); C07D 279/00 (20060101); C07D 417/00 (20060101); C07C 303/40 (20060101); C07C 303/00 (20060101); C07D 279/16 ()

Expiration Date: 06/26/2018