Patent Number: 6,252,075

Title: Process for producing purine derivatives

Abstract: A process for preparing 7-benzylpurine derivatives is provided. An acetylpurine nucleoside is reacted with a benzyl halide to benzylate the 7-position of the purine base, and an acid is then added to the reaction mixture to hydrolyze the glycoside bond. The 7-benzylpurines may be used to prepare 9-substituted purine derivatives. Specifically, a process for producing a 7-benzylpurine compound of Formula (5): ##STR1##

Inventors: Shiragami; Hiroshi (Kawasaki, JP), Izawa; Kunisuke (Kawasaki, JP), Yamashita; Keizo (Kawasaki, JP), Katayama; Satoshi (Kawasaki, JP)

Assignee: Ajinomoto Co., Inc.

International Classification: C07D 473/18 (20060101); C07D 473/00 (20060101); C07D 405/06 (); C07D 473/18 (); C07D 473/34 (); C07D 473/16 (); C07D 317/06 ()

Expiration Date: 06/26/2018