Patent Number: 6,252,076

Title: Process for preparation of pyrimidine derivatives

Abstract: The present invention relates, first to a process for preparation of 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquin olin-2-yl)pyrimidine represented by formula (I) and its acid addition salts, second, to a process for preparation of an intermediate for preparing the compound (I), and, third, to a novel intermediate compound. More specifically, the present invention relates, first, to a process for preparation of 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl,1,2,3,4-tetrahydroisoquin olin-2-yl)pyrimidine represented by formula (I), and its acid addition salts by reacting a pyrimidine derivative represented by formula (II-A), in which Hal represents a halogen, with 1-methyl-1,2,3,4-tetrahydroisoquinoline represented by formula (III), second, to a process for preparing of the pyrimidine derivative of formula (II-A) and the compound of formula (III); and, third, to a novel intermediate compound including the pyrimidine derivative of formula (II-A). ##STR1##

Inventors: Hong; You Wha (Kyonggi-do, KR), Lee; Young Nam (Kyonggi-do, KR), Kim; Hong Bae (Kyonggi-do, KR)

Assignee: Yuhan Corporation

International Classification: C07D 239/00 (20060101); C07D 239/42 (20060101); C07D 217/00 (20060101); C07D 217/02 (20060101); C07D 401/00 (20060101); C07D 401/04 (20060101); C07D 239/30 (); C07D 239/42 ()

Expiration Date: 06/26/2018