Patent Number: 6,252,081

Title: Process for production of donepezil derivative

Abstract: The present invention provides a novel industrially or economically preferable process for production of a hydrogen halogenide salt of a Donepezil derivative having an excellent pharmacological action as medicament, namely, reaction of 1-indanone derivative with carbonate ester to obtain 2-alkoxycarbonyl-1-indanone derivative, followed by reaction with halogenated (4-pyridyl)methyl or a salt thereof and decarboxylation successively to obtain 2-(4-pyridyl)methyl-1-indanone derivative, then reaction with halogenated benzyl to obtain quaternary ammonium salt, then reduction, and synthetic intermediates thereof. ##STR1## (Wherein R.sup.1 represents a hydrogen atom or lower alkoxy; n represents an integer of 1 to 4; R.sup.2 represents lower alkyl group; and X represents a halogen atom.)

Inventors: Iimura; Yoichi (Ibaraki, JP)

Assignee: Eisai Co., Ltd.

International Classification: C07D 211/32 (20060101); C07D 213/50 (20060101); C07D 213/00 (20060101); C07D 211/00 (20060101); C07D 213/50 (); C07D 211/32 ()

Expiration Date: 06/26/2018