Patent Number: 6,252,082

Title: Pyridone derivatives, their preparation and their use as synthesis intermediates

Abstract: The invention concerns compounds of formula (I) ##STR1## in which: R is --NO.sub.2 or --NHR.sub.3, R.sub.3 being hydrogen, --COR.sub.4 (R.sub.4 selected among (C.sub.1 -C.sub.4) alkyl, aryl and aryl (C.sub.1 -C.sub.4) alkyl, --COOR.sub.5 (R.sub.5 selected among (C.sub.1 -C.sub.4) alkyl and aryl (C.sub.1 -C.sub.4) alkyl), --CONHR.sub.6 or SO.sub.2 R.sub.6 (R.sub.6 selected among (C.sub.1 -C.sub.5) alkyl, aryl and aryl(C.sub.1 -C.sub.4) alkyl), --SO.sub.2 NR.sub.7 R.sub.8 (R.sub.7 and R.sub.8 independently of each other represent hydrogen or (C.sub.1 -C.sub.4) alkyl or form with the nitrogen atom a morpholine group), aryl (C.sub.1 -C.sub.4) alkyl, R.sub.1 is a (C.sub.1 -C.sub.4) alkyl group linear or branched, cyclo (C.sub.3 -C.sub.8) alkyl, aryl optionally substituted, aryl (C.sub.1 -C.sub.4) alkyl optionally substituted, heteroaryl, R.sub.2 is a hydrogen atom, a (C.sub.1 -C.sub.4) alkyl or arylmethyl group, X is an oxygen or sulphur atom, a --CH.sub.2 --, --SO.sub.2 or --NR.sub.1 -- group and Y is a hydrogen atom or (C.sub.1 -C.sub.6) alkyl. The invention is applicable to synthesis intermediates.

Inventors: Lassalle; Gilbert (Les Molieres, FR), Bellevergue; Patrice (Paris, FR), Bourbier; Jean-Claude (Bretigny sur Orge, FR), Galtier; Daniel (Guyancourt, FR), Martin; Valerie (Villejuif, FR)

Assignee: Sanofi-Synthelabo

International Classification: C07D 213/00 (20060101); C07D 213/69 (20060101); C07D 213/73 (20060101); C07D 409/00 (20060101); C07D 213/64 (20060101); C07D 213/70 (20060101); C07D 213/75 (20060101); C07D 409/06 (20060101); C07D 213/76 (20060101); C07D 213/71 (20060101); C07D 211/86 ()

Expiration Date: 06/26/2018