Patent Number: 6,252,086

Title: 4-alkenyl-and 4-alkynyloxindoles

Abstract: Disclosed are novel 4-alkenyl- and 4-alkynyl oxindoles having the formula ##STR1## and the pharmaceutically acceptable salts thereof. These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer, more particularly, the treatment or control of breast and colon tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and II as well as intermediates useful in the preparation of the compounds of formula I and II.

Inventors: Chen; Yi (Nutley, NJ), Dermatakis; Apostolos (North Brunswick, NJ), Luk; Kin-Chun (North Caldwell, NJ)

Assignee: Hoffmann-La Roche Inc.

International Classification: C07D 405/00 (20060101); C07D 403/14 (20060101); C07D 405/14 (20060101); C07D 409/00 (20060101); C07D 403/06 (20060101); C07D 409/14 (20060101); C07D 401/00 (20060101); C07D 403/00 (20060101); C07D 401/14 (20060101); C07D 403/06 (); A61K 031/417 ()

Expiration Date: 06/26/2018