Patent Number: 6,252,089

Title: Method of producing 4-hydroxy-2-pyrrolidinone and method of purifying the same

Abstract: 4-Hydroxy-2-pyrrolidinone which is useful as a raw material of drugs can be produced rapidly and highly selectively in a high yield from an optically active or recemic 4-amino-3-hydroxybutylic acid derivative or a 4-azido-3-hydroxybutyric acid derivative by adding a base catalyst to the reaction system. 4-Hydroxy-2-pyrrolidinone having a high optical purity can be obtained by carrying out recrystallization of optically active 4-hydroxy-2-pyrrolidinone without using a poor solvent.

Inventors: Nishikawa; Masahiro (Niigata, JP)

Assignee: Daicel Chemical Industries, Ltd.

International Classification: C07D 207/12 (20060101); C07D 207/00 (20060101); C07D 207/12 ()

Expiration Date: 06/26/2018