Patent Number: 6,252,131

Title: Transgenic mammal having 5-HT3 transgene overexpression in the CMS

Abstract: The invention relates to transgenic mammals characterized by 5-HT.sub.3 receptor over-expression in the central nervous system (CNS) . The mammals have particular utility as models for studying the role of 5-HT.sub.3 receptors in the CNS, especially for the study of reward pathways for alcohol and other substances of abuse.

Inventors: Allan; Andrea M. (Albuquerque, NM), Engel; Sharon R. (Winston-Salem, NC), Lyons; Clifford R. (Albuquerque, NM)

Assignee: University of New Mexico

International Classification: C07K 14/435 (20060101); C07K 14/705 (20060101); C12N 15/85 (20060101); A01K 067/027 (); C12N 005/00 (); C07H 021/02 ()

Expiration Date: 06/26/2018